Author: Torchilin, Vladimir P. Publisher: Bentham Science Publishers.
Keywords: diagnostic agents ; drug targeting ; intracellular drug delivery ; nanocarriers ; pharmaceutical carriers ; polyethylene glycollipid conjugates ; polymeric micelles ; poorly soluble drugs. Toggle navigation.
Micelles, self-assembling nanosized colloidal particles with a hydrophobic core and hydrophilic shell are currently successfully used for the solubilization of various poorly soluble pharmaceuticals and demonstrate a series of attractive properties as drug carriers. Polymeric micelles, i. Among those micelles, lipid-core micelles, i. These micelles can effectively solubilize a broad variety of poorly soluble drugs anticancer drugs in particular and diagnostic agents.
Drug-loaded lipid-core micelles can spontaneously target body areas with compromised vasculature tumors, infarcts via the enhanced permeability and retention EPR effect.
Lipid-core mixed micelles containing certain specific components such as positively charged lipids are capable of escaping endosomes delivering incorporated drugs directly into the cell cytoplasm. Various specific targeting ligand molecules such as antibodies can be attached to the surface of the lipid-core micelles and bring drug-loaded micelles to and into target cells.
Lipid-core micelles carrying various reporter contrast groups may become the imaging agents of choice in different imaging modalities. Keywords: diagnostic agents ; drug targeting ; intracellular drug delivery ; nanocarriers ; pharmaceutical carriers ; polyethylene glycollipid conjugates ; polymeric micelles ; poorly soluble drugs Document Type: Review Article Affiliations: Department of Pharmaceutical Sciences, Northeastern University, Boston, MA , USA.
Publication date: October 1, More about this publication?
The aim of Current Drug Delivery is to publish peer-reviewed articles, short communications, short and in-depth reviews in the rapidly developing field of drug delivery. Modern drug research aims to build in delivery properties of a drug at the design phase, however in many cases this ideal cannot be met and the development of delivery systems becomes as important as the development as the drugs themselves.
The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars.
The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery. Tools Activate personal subscription.
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